Mechnicov Institute of Microbiology and Immunology (16K)

Drug-design Laboratory

 
Main publications
  1. Lisnyak Yu.V., Gubskaya A.V. Molecular Modelling Study of beta-Cyclodextrin Inclusion Complexes with Some Methyl Xanthine Derivatives. "Problems of Biological and Medical Physics".- 1-st Ukrainiam Scientific Conference.- 2004.- Conf. Proc.
  2. Lisnyak Yu.V., Kosevich M.V., Gubskaya A.V. Conformational Possibilities of Glycerol. Vestnik Kharkovskogo Universiteta.-Biophysical Bulletin (Russ).- 2004.
  3. Levitin E.Ya., Lisnyak Yu.V., Shapoval O.V., Rudenko L.M., Maslyanchuk O.A., Yaremchuk A.A., Davidenko M.B. Elements of Pharmacophore for Substituted Bezylidenhydrazides 4-R-2-Chlorobenzoic Acid which have Antiviral Activity. Annals of Mechnikov Institute (Russ).- 2003, N 3-4.- P. 79-82.
  4. Volyansky A.Yu., Pasechnik T.O., Tolstanov A.K., Lisnyak Yu.V. Targets of Antibiotics and Dependences between their Structure and Activity. Annales of Mechnikov Institute (Russ).- 2001, N 1.- P. 39-41.
  5. Andrievsky G.V., Lisnyak Yu.V., Klochkov V.K., Volyansky Yu.L. 252 Cf-Plasma Desorption Mass Spectrometric Study of Quinolinium Salts and Method of Estimation of their Molecular Interactions with Phospholipids. International Journal of Mass Spectrometry and Ion Processes, 1997, vol.164, p.1-11.
  6. Gubskaya A.V., Aksyonov S.A., Kalinkevich A.N., Lisnyak Yu.V., Chuev V.P., Chivanov V.D. 252 Cf-Plasma Desorption Mass Spectrometric Study of the Inclusion Complexes of Cyclodextrins with Coumarins. Rapid Communications in Mass Spectrometry, 1997, vol.11, p.1874-1878.
  7. Gubskaya A.V., Lisnyak Yu.V., Blagoy Yu.P. Effect of cryogrinding on Physico-Chemical Properties of Drugs. I.Theophilline: Evaluation of Particles Sizes and the Degree of Crystallinity, Relation to Dissolution Parameters. Drug Development and Industrial Pharmacy, 1995, vol.21, N 17, p.1953-1964.
  8. Gubskaya A.V., Chishko K.A., Lisnyak Yu.V., Blagoy Yu.P. Effect of Cryogrinding on Physico-Chemical Properties of Drugs. II. Cortisone Acetate: Particle Sizes and Polymorphic Transition. Drug Development and Industrial Pharmacy, 1995, vol.21, N 17, p.1965-1974.
  9. Lisnyak Yu.V., Kuchma I.Yu., Khater S.Kh.A., Paliy V.G. Quinolinium Derivatives: Molecular Shape and Antimicrobial Activity. "Synthesis, Experimental Study and Clinical Use of Quaternary Ammonium Compounds", Chernovcy (Ukraine), 8-10 October, 1995. Symposium Proc. (Russ), p. 39.
  10. Lisnyak Yu.V., Volyansky Yu.L. Conformation-Function Relations of Styrylquinolinium Derivatives Molecules. "Synthesis, Experimental Study and Clinical Use of Quaternary Ammonium Compounds", Chernovcy (Ukraine), 8-10 October, 1995. Symposium Proc.(Russ), p. 38.
  11. Andrievsky G.V., Lisnyak Yu.V., Volyansky Yu.L., Malaya L.T. Mass-Spectrometric Analysis of Fragmentation Peculiarities of Quinolinium Dimethine Derivatives. Ibid, p. 3.
  12. Andrievsky G.V., Lisnyak Yu.V., Volyansky Yu.L., Malaya L.T. Mass-Spectrometric Study of Supramolecular Complexes of Quinolinium Derivatives with Phospholipids. Ibid, p. 4.
  13. Lisnyak Yu.V., Volyansky Yu.L., Kolyada T.I., et al. Information Analysis Use for Evaluation of Immune System Status. International Journal of Immunorehabilitation, 1995. (International Congress on Rehabilitation in Medicine, Sochi (Dagomys), July 6-10, 1995).
  14. Lisnyak Yu.V. Computer-Assisted Design of Drugs and Biomolecules. "I.Mechnikov Ideas and Development of Modern Natural Science", International Sci.Conf., devoted to I.Mechnikov Bithday 150 Anniversary. Kharkov, November, 1995. Conf. Proc.(Russ), Kharkov, 1995, p.180-181
  15. Borodavko Yu.M., Kolyada T.I., Lisnyak Yu.V., et al. Elements of Information Theory in Evaluation of the Population Immune Status and the Process of Adaptation. Ibid, p.44-45.
  16. Primakov D.A., Lisnyak Yu.V. Automatized Work Place of Immunology Doctor. Ibid, p.246-247.
  17. Lisnyak Yu.V., Chernyavsky V.I., Lisenko A.I. et al. System Approach to Evaluation of Patients Immune Status and Efficiency of Immuno-Corrective Therapy. Ibid, p.181-182.
  18. Volyansky Yu.L., Kuchma I.Yu., Lisnyak Yu.V., et al. Computer Simulation in the Search of Antimicrobial Agents: Principles, Approaches, Methods (Russ). Osnova, Kharkov, 1994. 208 p.
  19. Vasiliev N.V., Volyansky Yu.L.,Kolyada T.I., Lisnyak Yu.V.,et al. Possibilities of Expert System Use in Evaluation of Human Immune Status. International Journal of Immunorehabilitation(Russ), 1994, N 1 - Supplement, p.369-370. (Abstracts of the I International Congress on Immunorehabilitation). (Sochi (Dagomys), July 5-9, 1994)
  20. Gubskaya A.V., Lisnyak Yu.V., Khomenko V.G., et al. Morphological and Structural Characteristics of Cryogrinded Cortisone Acetate. Doklady Acad. Nauk, Ukraine (Russ), 1992, 12, p.86-89.
  21. Gubskaya A.V., Telezhenko Yu.V., Lisnyak Yu.V., Sukhodub L.F. Effect of Low Temperature Grinding on Structural Characteristics of Drugs. Fifth All-Union Conf. on Low Temperature Chemistry, Moscow, December, 10-13, 1991. Conf. Proc.(Russ), Moscow, 1991, p.145-146
  22. Poltev V.I., Lisnyak Yu.V., Teplukhin A.V. Monte Carlo Simulation of the Hydration of Wrong Base Pairs of Nucleic Acids. Molekulyarnaya Biologia (Russ), 1990, 24, p.1640-1648.
  23. Lisnyak Yu.V., Telezhenko Yu.V., Volyansky Yu.L. Theoretical Analysis of Conformations of Dimethylaminostyryl Quinolinium Derivatives. VIII All-Union Sympos. on Intermolecular Interaction and Molecular Conformations. Novosibirsk, October 28 - November 1, 1990. Conf.Proc.(Russ), Novosibirsk, 1990, I, p.110.
  24. Chernyavsky V.I., Lisnyak Yu.V., Kozin Yu.I. Efficiency Evaluation of Immuno-Corrective Therapy by Linear Discriminant Analysis. II Internat. Symp., Rehabilitation of Immune System, Dagomys, 1990. Conf. Proc.(Russ), Tshaltubo, 1990, p.14.
  25. Lisnyak Yu.V. Monte Carlo Simulation of the Hydration of Wrong Base Pairs. 21 Conf. of Young Scientist, ILTPE /Institute for Low Temperature Physics and Engineering/, Academy of Sciences of Ukraine, May 21-25, 1990. Conf. Proc.(Russ), Kharkov, 1990.- P.96-97.
  26. Lisnyak Yu.V. Linear Discriminant Analysis Use for Efficiency Evaluation of Immuno-Corrective Therapy. Ibid, p.98-99.
  27. Lisnyak Yu.V., Telezhenko Yu.V., Sukhodub L.F., Volyansky Yu.L. Theoretical Analysis of Conformations of 1-Alkyl-Substituted 2-(p-Dimethylaminostyryl) Quinolinium Derivatives. Preprint ILTPE (Russ)/Institute for Low Temperature Physics and Engineering/, Academy of Sciences of Ukraine, Kharkov, 1989, N 32-89, p.1-23.
  28. Verkin B.I., Gubskaya A.V., Lisnyak Yu.V. et al. Effect of Cryogrinding on Structural Characteristics of Theophylline. Doklady Acad. Nauk USSR (Russ).- 1988, 301.- p.1128-1131.
  29. Lisnyak Yu.V., Telezhenko Yu.V. The Investigation of Internal Rotation and Relative Stability of Rotamers of Stilbene. Preprint ILTPE (Russ)/Institute for Low Temperature Physics and Engineering/, Academy of Sciences of Ukraine, Kharkov, 1987, N 7-87, p.1-21.
  30. Lisnyak Yu.V., Telezhenko Yu.V., Volyansky Yu.L. Theoretical Conformational Analysis of Model Compounds for Dimethine Quinoline Derivatives. Ukrainian Sci. Conf.(Russ), Kharkov, 1987. Conf. Proc., Kharkov, 1987, p.176-177.
  31. Lisnyak Yu.V., Telezhenko Yu.V. Theoretical Analysis of Conformations of Quinaldinium Derivatives. Scientific Conf., devoted to I.Mechnikov Institute's 100-th Anniversary. Kharkov, April, 1987. Conf. Proc.(Russ), Kharkov, 1987, p.10.
  32. Lisnyak Yu.V., Telezhenko Yu.V., Volyansky Yu.V. The Investigation of Three-Dimensional Structure Dependence of Biological Activity in the Series of Quinolinium Derivatives. Ukrainian Conf. of Young Scientist, Public Health Department, Odessa, 1986. Conf. Present., Odessa, 1986.
  33. Sukhodub L.F., Telezhenko Yu.V., Shelkovsky V.S., Lisnyak Yu.V. Enthalpies of Small Water Clusters. Preprint ILTPE (Russ)/Institute for Low Temperature Physics and Engineering/, Academy of Sciences of Ukraine, Kharkov, 1984, N 27-84, p.1-26.
  34. Sukhodub L.F., Telezhenko Yu.V., Shelkovsky V.S., Lisnyak Yu.V. Thermodynamic Characteristics of Small Water Clusters. II All-Union Conf. on Theoretical and Applied Cryobiology, Kharkov, 1984. Conf. Proc.(Russ), Kharkov, 1984, I, p.89.
  35. Sorokin V.A., Blagoy Yu.P., Valeev V.A., Lisnyak Yu.V. Studies of Calcium Ion Binding to Poly A. Journal of Inorganic Biochemistry, 1983, 19, p.143-152.

Research units

 
 
Microbiology units
Clinical Microbiology Laboratory
Specific Prophylactics of Drop Infection Laboratory
Viral Infections Laboratory
New and Unexplored Infection Laboratory
Antibacterial Agents Laboratory
Ecological and Epidemiological Monitoring Laboratory
Microorganisms and Mediums Biochemistry Laboratory
 
Immunology units
Immunorehabilitation Laboratory
Clinical Immunology and Allergology Laboratory
Drug-design Laboratory
Clinical Immunological Department
 
Museum of Pathogenic for People Microorganisms
 
Immunoprophylaxis and Immunorehabilitation Centre
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