Antibacterial Agents Laboratory

A leading direction of scientific activity of laboratory is development, studying and application in medical practice of new highly effective medical products on the basis of natural and synthetic compositions for treatment of diseases microbic's etiology.

Main scientific areas of the laboratory:

1. НИР АМН № 67/2005 "The influence of supplement substances on the enhancement of biological activity of antibiotics in the therapeutical agents".
2. НИР АМН № 66/2005 "Development of the antimicrobial agent on the basis of biologically active substances of Humulus lupulus L. for treatment of infectious and purulent-inflammatory diseases".
3. НИР АМН 81/2008 "The determination of the chemical substances with antimicrobial activity among the synthetic cumarine derivatives and their heteroanalogsfor further application in the new therapeutical agents development".
4. НИР АМН 82/2008 "The development of a therapeutical agent on the basis of hop products for up-per airways diseases treatment".

Kazmirchuk V.V.
Head of laboratory

Stuff:

• Victor V. Kazmirchuk - Head of the laboratory, Ph. D. in Medicine, senior research worker
• Ioanna F. Belokon - the leading research worker, Ph. D. in Pharmacology
• Natalia N. Shulga - senior research worker, Ph. D. in Biology
• Irina D. Andreeva - senior research worker, Ph. D. in Medicine
• Elena A. Radchenko - senior research worker
• Nadia A. Volaynskay - research worker
• Vera I. Uchimenko - research worker
• Tatyana L. Klysa - research worker
• Victoria U. Evsukova - research worker
• Inna V. Povolokina - junior research worker
• Elena O. Chumachenko - junior research worker
• Vera D. Skripnik - the laboratorian
• Irina N. Ivanova - the laboratorian
• Nadia I. Miroshnik - the laboratorian

Publications for 2006 - 2009:

Total of publications 37, from them 1 patent, the circular on an innovation in system of health protection, methodical instructions{indications}, 23 clauses{articles} in scientific magazines and collections, 22 theses of reports at scientific conferences.

1. S.L. Krestetska, M.G. Krestetsky, V.V. Kazmirchuk, A.J. Volaynskay, O.M. Koljada "Latent infec-tion as risk factor of rapid progress of atherosclerotic process" // Анали Мечниковського Інституту. - 2006. - № 1.
2. Zhuravel I.A., Kovalenko S.M., Evsjukova V.U. "Synthesis and antimicrobial activity of 2Н-pirano [2,3-с] pyridine derivatives". - International practical scientific conference "Current problems of strat-egy, application tactics and research of antibiotics, antiseptics and desinfectants"". - Vinniza. - 2006. - С. 246.
3. Vlasov S.V., Konovalenko S.M., Kazmirchuk V.V., Chernich V.P., Shulga N.N. "Antimicrobial ac-tivity of condensed 3(cumarin-2-ІЛ)-2Н,6Н-pyrimido [1,23,4] tiadiazine-6 derivatives". - International practical scientific conference "Current problems of strategy, application tactics and research of antibi-otics, antiseptics and desinfectants"". - Vinniza. - 2006. - С. 242.
4. Borisov A.V., Zhuravel I.A., Evsjukova V.U., Plehov A.V., Kovalenko S.N. "The study of reactive activity of 2-N -ariliminocumarin- 3-thiocarboxymides and their 7-azaanalogs"// Materials of the second international conference "Development, production, standardization and pharmacoeconomic re-search of new therapeutical agents and biologically active nutritional supplement". - Kharkov. - 2006. -NPAU. - С. 7.
5. Borisov A.V., Zhuravel I.A., Evsjukova V.U., Kovalenko S.N. "Sythesis and antimicrobial activity of 2-N-ariliminocumarin-3-thiocarboxymides AND THEIR 7-azaanalogs chemical reaction products" International practical scientific conference "The search and development of new immunobiological agents, prophylactic and therapeutical antimicrobial agents, antiseptics, desinfectants and probiotics". - Kharkov. - 2006.
6. Spiridonova N.V., Silin O.V., Evsjukova V.U., Kovalenko S.M. "Synthesis of sulphur derivatives of 6-fluorochinolins-4 and their antimicrobial activivity" International practical scientific conference "The search and development of new immunobiological agents, prophylactic and therapeutical antimicrobial agents, antiseptics, desinfectants and probiotics". - Kharkov. - 2006.
7. Brusnik S.V., I.I. Toraynik, А.V. Bakumenko, N.G. Popova, L.А. Popova, Evsjukova V.U., Scher-bak O.N., "The role of herpesviruses in patients of chronic fatigue syndrome" International practical scientific conference "The search and development of new immunobiological agents, prophylactic and therapeutical antimicrobial agents, antiseptics, desinfectants and probiotics". - Kharkov. - 2006.
8. Spiridonova N.V., Silin O.V., Kovalenko S.M., V.V. Kazmirchuk, Sorokoumova L. K., Lipko P.M. "Synthesis and prognosis of biological activity of sulphur derivatives 6-fluorochinolins-4". - Interna-tional practical scientific conference "The search and development of new immunobiological agents, prophylactic and therapeutical antimicrobial agents, antiseptics, desinfectants and probiotics". - Kharkov. - 2006. - С. 248.
9. Ilchenko О.V., Zaremba О.V., Sheraykova А.А., Kovalenko S.M., Chernich S.М., Kazmirchuk V.V. "Antimicrobial activity of 2-[(3-substituted-4-oxy-3,4-bihydro[1]benzofuro [3,2-D] pyrimidin-2-ІЛ)sulfanil-N-alkil (aril) acetamines. - Materials of the second international conference "Development, production, standardization and pharmacoeconomic research of new therapeutical agents and biologi-cally active nutritional supplement". - Kharkov. - 2006. -NPAU. - С. 14.
10. Kazmirchuk V.V., Layshenco N.I., Spiridonov A.V., Voljanskay N.А., Shulga N.N., Sorokoumova L. K., Radchenco Е.А., Chumachenco Е.O. "Antimicrobial activivty of lypophil extract of Humulus lupulus l.". - Materials of the second international conference "Development, production, standardiza-tion and pharmacoeconomic research of new therapeutical agents and biologically active nutritional supplement". - Kharkov. - 2006. -NPAU. - С. 54.
11. Brusnik S.V., Andreeva I.D., Scherbak O.N., Evsjukova V.U., Koljada O.M. "Immune response pa-rameters on the model of radiation - induced immunodeficiency" Materials of practical scientific con-ference "Annual therapeutic readings: the role of medical science in solving of the inner disease prob-lems". - 2007. - С. 23.
12. A.V. Spiridonov, V.V. Kazmirchuk, N.A. Volyanskay, I. U. Kuchma "Antimicrobial agents with coating and adsorbent substances of herbal origin" // Materials of international practical scientific con-ference "Current problems of phytodesign" / Belgorod . - May 28 - 31 2007 г.
13. Evsjukova V.U., S.L. Krestetska, D.L. Voljansky D.L., Kazmirchuk "Antitransduction effect of quarternary acrydine salts" Practical scientific conference "Current problems of microorganisms ecol-ogy". - Ternopil TSMU "Ukrmdekniga". - С. 44 - 45.
14. Nesterenko A.M., Scherbak O.N., Evsjukova V.U., Koljada O.M., Brusnik S.V., Andreeva I.D., Koljada T.I. "Natural resistance on the model of radiation - induced immune deficiency// "Immunology and allergology". - Kiev. - № 2. - 2007. - P. 99
15. S.V. Brusnik, І.P. Yudin, I.D. Andreeva, O.M. Scherbak, Evsjukova V.U., T.V. Luk'janenko, М.S. Міchаylіchеnко, V.M. Egоshinа "The influence of cycloferon on the complement level in the infectious process on the background of antenatal irradiation in experiment" // "Perinatology and pediatrics". - № 3(31). - 2007. -Part II. - Report theses of the VII Ukrainian practical scientific conference "Immunol-ogy problems in pediatrics". - p. 18.
16. V.V. Kazmirchuk, O.O. Kulikova, L.O. Panchenko, N.G. Popova, І .В. "Medical agents in the treat-ment and prophylaxis of herpersvirus infection" // Reference issue. - Kharkov. - 2007. - p. 71.
17. E.A. Panchenko, E.A. Kulikova, V.V. Kazmirchuk, I.I. Torjanik, І .О. Zhuravel, V.V. Grabar "Her-pes. Diagnostics, treatment and prophylaxis" // Monograph. - Харків. - 2007. - p. 150.
18. V.V. Kazmirchuk, A.S. Detistov, I.A. Zhuravel, S.N. Kovalenko "Synthesis and antimicrobial activ-ity of the 3-[1,2,4-oxadizol 5-il]cumarines" - The journal of organic and pharm. chemistry. - 2007. - Т.5, V. 4(20). - p. 41 - 43.
19. V.V. Kazmirchuk, I.F. Belokon, Evsjukova V.U. The development of antimicrobial agents with en-hanced specific activity //Annals of Mechnikov Institute. 2007.- №4. - С.39-42.
20. Belokon I.F., Evsjukova V.U., Shulga N.N., Povolokina I.V., Uchimenko V.I., N. A.Volaynskay / Some aspects of enhancement of antimicrobial agents specific activity // Annals of Mechnikov Institute. -2007.- № 4 (Online. hutl. ru)
21. Sklyar N.I., Brusnik S.V., Andreeva І .D., Scherbak O.M., Evsjukova V.U., Koljada O.M. "The in-fluence of irradiation on the course of infectious process in experiment" Materials of practical scientific conference "Annual therapeutic readings: the role of medical science in solving of the inner disease problems". - 2007. - С. 140
22. Belokon I. F.,Volaynsky U.L., Kazmirchuk V.V. "Polidecanit" - antimicrobial agent for treatment of the gastrointestinal tract diseases //Today and future of pharmacy. Theses. Kharkov. - 2008. - p. 245.
23. V.V. Kazmirchuk, Spiridonov A.V., Nadtoka V.L., Shulga N.N., Djachenko V.F., Voljanska N.A., Peretjatko O.G. "The development of antimicrobial agents on the basis of hop products" Ukrainian congress Today and future of pharmacy. Theses. - April 16 - 19, 2008. - Kharkov. - p. 265.
24. Voljansky U.L., Belokon I. F., V.V. Kazmirchuk, Shulga N.N., Povolokina I.V., Uchimenko V.I., Chumachenko E.O., Makarenko V.D. "Development of antimicrobial compositions for infectious dis-eases treatment" Ukrainian congress Today and future of pharmacy. Theses. - April 16 - 19, 2008. - Kharkov. - p. 252.
25. Kazmirchuk V.V., Evsjukova V.U., Belokon I. F., Radchenko E.A., Makarenko V.D. "Current problems of development and research of highly effective antimicrobial compositions" Ukrainian con-gress Today and future of pharmacy. Theses. - April 16 - 19, 2008. - Kharkov. - p. 261.
26. V.V. Kazmirchuk, S.M. Kovalenko, S.V. Vlasov, А.І. Fedosov, В.P.Chernich Synthesis and antim-icrobial activity of the 7-methil-6-oxy-2Н,6Н-thieno [2?,3?:4,5]pyrimido [2,1-b][1,3,4]thiazidin-8-carboxylic acid derivatives. Pharmacy herald. - № 1 (53) 2008. - Kharkov. - p. 3 - 7.
27. Radchenko E.A., Pavlenko N.V. "Modern therapeutical agents from propolis with antibacterial and antivirus activity". Materials of practical scientific conderence with international participation. March 27 - 28, 2008 "Infections in clinical practice. Antibacterial and antivirus therapy on the pre-hospitalization and hospitalization stage". - p. 285.
28. Belokon I. F. Some technological aspects of kids therapeutical agents developmen // Ukrainian con-gress Today and future of pharmacy. Theses. - April 16 - 19, 2008 . - Kharkov. - - С. 244.
29. Zhuravel I.A., Borisov А.V., Kovalenko S.M., Kazmirchuk V.V., Sorokoumova L. K., Shevchuk N.М. "The search of substances with antimicrobial activity among the 4Н-pyrido [4?,3?:5,6]pyrano [2,3-D]pyrimidin derivatives" // International practical scientific conference "Current problems of strategy, application tactics and research of antibiotics, antiseptics and desinfectants"". Theses. - Octover 9-10, 2008- Vinniza. - p. 190.
30. Nechaev М.А., Shinkarenko P.E., Kovalenko S.M., Shulga N.N., Evsjukova V.U., Sorokoumova L. K. "Antimicrobial activity of izotiazol [4,5- D]pyrimidin derivatives" International practical scientific conference "Current problems of strategy, application tactics and research of antibiotics, antiseptics and desinfectants"". Theses. - Octover 9-10, 2008- Vinniza. -- p. 190-191.
31. Belokon I. F., Peretaytko E.V., Makarenko N.N., Shulga N.N., Evsjukova V.U., Povolokina I.V., Uchimenco V.І., Radchenko E.А., Chigirinskay N.А., Kazmirchuk V.V. "The development and re-search of nitazol and decametoxin optimal compositions with antibiotics" "Chronic gut diseases in chil-dren": Materials of practical scientific conference with international participation dedicated to the 85-th anniversary of the chair of pediatric gastroenterology and nutritiology of KhMAPO. - Kharkov. - 2008. - p. 20.
32. Evsjukova V.U., Scherbak O.N. "Antifungal and antimicrobial activity of nitrogen-containing con-densed systems derivatives" // Materials of ХІІІ International congress of students and young scientists. / Ternopol. - April 27 - 29, 2009.
33. Evsjukova V.U., Andreeva І .D., Scherbak O.N., Kazmirchuk V.V. "Specific antimicrobial activity of synthetic cumarine derivatives and their heteroanalogs towards grampositive microorganisms" // Ma-terials of practical scientific conference "Annual therapeutic readings: modern therapy and its general role in the clinical inner diseases". - Stand report. April 9 - 10, 2009. - Kharkov. - 2009. - p. 62.
34. Kazmirchuk V.V., Layshenko N.І., Andreeva І .D., Evsjukova V.U., Shulga N.N., Makarenko V.D, Voljanskay N.A., Volkov Т.А. "The study of antimicrobial activity of thick Humulus lupulus L extract with the serial dilutions method". - Materials of practical scientific conference "Annual therapeutic readings: modern therapy and its general role in the clinical inner diseases". - April 9 - 10, 2009. - Kharkov. - 2009. - p.74.
35. Kazmirchuk V.V., Layshenko N.І., Andreeva І .D., Shulga N.N., Makarenko V.D, Grigorchuk О.А., Suchachova С.М. "The study of antimicrobial activity of thick Humulus lupulus L extract with the diffusion into agar method". - Materials of practical scientific conference "Annual therapeutic read-ings: modern therapy and its general role in the clinical inner diseases". - April 9 - 10, 2009. - Kharkov. - 2009. - p. 75.
36. Kazmirchuk V.V., Layshenko N.І., Andreeva І .D., Evsjukova V.U., Makarenko V.D, Volkov А.А., Shatilo U.V., Suchachova С.М., Chumachenko E.О. "Antimicrobial activity of the Humulus lu-pulus L. oil". - Materials of practical scientific conference "Annual therapeutic readings: modern ther-apy and its general role in the clinical inner diseases". - Stand report. April 9 - 10, 2009. - Kharkov. - 2009. - p. 76.
37. Scherbak O.N., Evsjukova V.U., Andreeva І .D., Kazmirchuk V.V. "Antimicrobial activity of syn-thethis cumarine derivatives and their heteroanalogs towards the gramnegative microorganisms" // Ma-terials of practical scientific conference "Annual therapeutic readings: modern therapy and its general role in the clinical inner diseases". - Stand report. April 9 - 10, 2009. - Kharkov. - 2009. - p. 228.